Etizolam marketed under many brand names is a thienodiazepine derivative  which is a benzodiazepine analog. It was patented in  and approved for medical use in Long term use may result in blepharospasms. In rare cases, erythema annulare centrifugum skin lesions have resulted. Abrupt or rapid discontinuation from etizolam, as with benzodiazepinesmay result in the appearance of the benzodiazepine withdrawal syndromeincluding rebound insomnia.
In a study that compared the effectiveness of etizolam, alprazolamand bromazepam for the treatment of generalized anxiety disorderall three drugs retained their effectiveness over 2 weeks, but etizolam became more effective from 2 weeks to 4 weeks, a type of reverse tolerance.
Etizolam, a thienodiazepine derivative, is absorbed fairly rapidly, with peak plasma levels achieved between 30 minutes and 2 hours. It has a mean elimination half life of about 3.
According to the Italian P. This new class is easily oxidizedrapidly metabolizedand has a lower risk of accumulation, even after prolonged treatment. Etizolam has an anxiolytic action about 6 times greater than that of diazepam. Etizolam produces, especially at higher dosages, a reduction in time taken to fall asleep, an increase in total sleep time, and a reduction in the number of awakenings. During tests, there were no substantial changes in deep sleep ; however, it may reduce REM sleep.
In EEG tests of healthy volunteers, etizolam showed some similar characteristics to tricyclic antidepressants. Etizolam's main metabolites in humans are alpha-hydroxyetizolam and 8-hydroxyetizolam. Alpha-hydroxyetizolam is pharmacologically active and has a half-life of approximately 8.
Itraconazole and fluvoxamine slow down the rate of elimination of etizolam, leading to accumulation of etizolam, therefore increasing its pharmacological effects. Cases of intentional suicide by overdose using etizolam in combination with GABA agonists have been reported. Flumazenila GABA antagonist agent used to reverse benzodiazepine overdoses, inhibits the effect of etizolam as well as classical benzodiazepines such as diazepam and chlordiazepoxide. Etizolam overdose deaths are rising - for instance, the National Records of Scotland report on drug-related deaths, implicated deaths from 'street' Etizolam inalmost double the number from and only six years from the first recorded death in Etizolam is a Schedule 4 substance under the Poisons Standard June as it is classed as a benzodiazepine derivative.
Etizolam was controlled in Germany in July Etizolam is licensed for the treatment of anxiety, insomnia and neurosis as a prescription-only medication. Etizolam also called Depas, is restricted as a benzodiazepine analog in Japan from October onwards.
In the UK, etizolam has been classified as a Class C drug by the May amendment to The Misuse of Drugs Act along with several other designer benzodiazepine drugs. Etizolam is not authorized by the FDA for medical use in the U. However, it currently remains unscheduled at the federal level and is legal for research purposes. As of Marchetizolam is a controlled substance in the following states: Alabama,  Arkansas,  Florida,  Georgia as Schedule IV, whereas all other states listed here prohibit it as a Schedule I substanceLouisiana, Mississippi,  Texas,  South Carolina,  and Virginia.
Etizolam is a drug of potential misuse. Cases of etizolam dependence have been documented in the medical literature. From Wikipedia, the free encyclopedia.
Unscheduled in the remaining states. IUPAC name. Interactive image. See also: Benzodiazepine overdose. See also: Benzodiazepine misuse. Alprazolam Brotizolam Clotiazepam Deschloroetizolam Metizolam Benzodiazepine dependence Benzodiazepine withdrawal syndrome Long-term effects of benzodiazepines.Etizolam is a benzodiazepine analogue from a class of drugs known as thienodiazepines and, like most drugs similar to benzodiazepines, it has amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and muscle-relaxing properties.
Etizolam does not currently have an accepted medical use in the United States. Etizolam is a very potent thienodiazepine. Etizolam has a very pronounced sedative effect approaching that of zolpidem Ambien. Users report feelings of significantly reduced anxiety, loss of inhibition, relaxation, sedation and euphoria. Users often consume etizolam as a pill, blotter paper or as a powder. Due to etizolams speed of absorption the two most common routes of administration are oral and sublingual.
A 1 milligram dose of etizolam corresponds to approximately 0. Typical doses range from 0. In countries where etizolam is marketed for medal use Japan, Italy, India it typically comes in 0. Etizolam is very well absorbed in the gastrointestinal tract, it quickly floods the brain and reaches peak levels anywhere from 30 minutes to two hours after ingestion.
The half-life is an important indicator of duration of action. At this time, due to it having no acceptable medical use in the US, etizolam is not controlled on a federal level in the United States. It is legal to use for research purposes. Etizolam can increase blood prolactin levels and potentially result in a condition known as hyperprolactinaemia. This condition may result in spontaneous production of breast milk, infertility, and disruptions of the menstrual cycle in women; and hypogonadism, infertility and erectile dysfunction in men.
Long term use of etizolam can cause blepharospasm, which is a condition categorized by abnormal contractions or twitches of one or both eyelids. In very rare cases etizolam has been noted to cause skin lesions. Etizolam, like all benzodiazepine-class drugs, has a high potential for addiction and can cause severe physical withdrawal symptoms with prolonged usage.
Withdrawal symptoms can manifest after sudden discontinuation of etizolam following just two weeks of daily dosing. Any dose of etizolam with noticeable effects taken on a long enough timeline can form a mental and physical dependence on the drug. Reports range from two weeks of daily use to a full month for first signs of physical addiction.
Individual biological differences and history of prior addiction both play a significant role. Some individuals develop mental and physical addiction more quickly than others.etizolam Powder
Etizolam withdrawal is known to be difficult and in certain cases even life threatening for those using large or moderate amounts for a prolonged period of time. One of the dangers with etizolam discontinuation is the risk of seizures. Additional withdrawal symptoms include anxiety, insomnia, dysphoria, and tremors. Like most of the benzodiazepines, many of the clinical symptoms initially treated by etizolam use in other countries, such as anxiety and insomnia, come back with increased potency during the period of withdrawal.
Physical and psychological etizolam withdrawal symptoms begin within hours following the last use and can last anywhere from a few days to several months depending on how long etizolam was used for and at what dosage.
Etizolam Questions and Answers
Users typically report withdrawal symptoms that last anywhere from several weeks to several months. Recovery Centers of America can provide the necessary medically supervised environment to undertake a safe and successful etizolam detox as well as providing continuing care once acute medical withdrawal is completed. At RCA we take a slow and controlled approach to tapering benzodiazepines.
This approach is widely accepted as the safest available and results in the least discomfort.
Additional medications such as antidepressants, anticonvulsants, beta-blockers, and others may be used for treating the symptoms during withdrawal. During the initial assessment and intake processes, RCA identifies family members or significant others who will support the patient and their treatment goals and get them involved immediately. After medical detoxification, treatment may include continuing small group therapy sessions, individual sessions, educational seminars, and workshops.
For patients struggling with etizolam or other benzodiazepine-like substances, or difficulties with anxiety or panic, additional services to assist with calming the body and the mind such as mindful meditation, yoga, progressive relaxation, and other therapeutic techniques will be offered.If you need to buy Etizolam powder ask our pro team any question you have.
Buying Etizolam you need to know that is sold under several brand names, such as Depas, Pasaden, Etizest, Sedekopan, Etizola and Etilaam. It has been used around the world as a muscle relaxant, a sedative, a hypnotic, an anticonvulsant and an anxiolytic. It is similar to substances such as Diclazepam and Flubromazepam. Etizolam is an analogue of benzodiazepine.
The two chief differences between the two is that the trizole ring in benzodiazepine has been fused and the benzene ring has been replaced with a thiopene ring.
Biologically, it is characterised by a much shorter half-life than the other similar to it, and will typically be metabolised into the body at a much higher rate. Etizolam is similar to most benzodiazepines in terms of its effects and side effects.
Its capacity as a sedative is substantial, and its ability to suppress anxiety and replace it with a pleasant sensation are some of the chief factors in its popularity.
Like other drugs, though, it is a hypnotic and an amnesic, so care should be taken with its use. Sedatives, of course, should never be mixed with alcohol.
Other side effects have been reported to occur with long term use or abuse. These include blepaharospasm and on very rare occasions skin lesions.
So how does it work?
Rebound Insomnia may also occur when long term use is discontinued. It is not controlled o the federal level in the US, but is controlled by several individual states, including:. However, it is the responsibility of the buyer to understand all of the relevant laws of their own countries.
You must ensure that your entire order is in full compliance with regulations and guidelines. We must stress that we sells chemicals such as Etizolam powder only for the purposes of in vitro research or other laboratory use. Save my name, email, and website in this browser for the next time I comment. Diclazepam Powder. Flubromazepam Powder. Log in Remember me. Lost your password? Add to Wishlist. Reviews There are no reviews yet. Related products. Sedatives Diclazepam Powder.
More Options. Stimulants 4-cl-pvp. Sedatives Flubromazepam Powder. Choose an option g 10g 1g 1kg g 25g g 50g 5g Clear.Last Updated: March 6, It is among the popular research chemicals used by researchers to perform their activities in different laboratories in the world. The chemical, also known as benzodiazepine analog, possesses high amounts of sedatives, anxiolytic, and hypnotic.
Also, the drug has the properties that help in the relaxation of the skeletal muscles. You can find the drugs in the form of tablets. Almost all types of drugs in the world are accessible in pills form. It simplifies their process of handling and consumption. Pills are perfect for the individuals who do not like the varieties of tastes of liquid medicine.
It can also be in the form of a soft powder. However, the powder form is not for patients but always used for performing different types of research. Distributing the powder in the industrial sector is easy. Although it is illegal in many countries in the world, some individuals use it for medicinal purposes.
As a medicine, many people use it for the treatment of numerous illnesses. It treats panic and anxiety disorders. Additionally, it is also a remedy for sleeplessness, stress disorders, and used as a short-term treatment of insomnia. It is a perfect solution for mental reflection of human beings. It helps people to forget stressful things that are disturbing them, but it can be fatal when an individual decides to use an overdose.
The second and common function of the chemical is performing research. As a powder, specialists and high-profile researchers use it in their procedures to perform extensive research. However, it is advisable always to wear gloves, masks, and other protective garments when performing research using it or other chemicals because most of them are toxic and they can bring harmful side effects to the human body.
Although many people use it for medicinal purposes, Etizolam can be dangerous when abused or when used for long-term treatment functions. When used to cure anxiety or stress disorders for a long time, it can slow the functionality of the brain.
Therefore, this may lead to forgetfulness or even loss of memory. It cures sleeplessness, but when used inappropriately, it can play a role in altering the moods or the thinking capabilities of the users. The condition may lead to loss of brain coordination in performing daily activities.
If the body loses coordination, the victim may start stammering or bring up invalid arguments in serious discussions. It can also be dangerous if the users mix it with other drugs or chemicals. For instance, if an individual uses it to treat some illnesses, he or she should not take alcoholic drinks. The chemical highly reacts with alcoholic substances.
Therefore, if the victim drinks alcohol after taking this medication, it can lead to his or her death or even other serious ailments. The chemical is highly addictive. When people start using it gradually for medicinal purposes or other reasons, they may find difficulties to cope with life effectively without taking some dosages of Etizolam. After consuming the chemical, it gets absorbed into the blood instantly. It mixes with the plasma, which plays a huge role in making it highly addictive.
Therefore, excessive usage of this drug can increase the risks of acquiring numerous illnesses and unwanted conditions to human beings.
Below are the precautions of the drug. Before purchasing this drug from a chemist, you should first inform your personal doctor about the other medications that you are currently using.Germany Restrictions Click Here.
Bloggers - Video Reviewers - Forum Reviewers wanted. Etizolam Powder from www. Etizolam Powderalso known as 7- 2-chlorophenyl - 4-ethyl- methyl- 3-thia- 1,8,11, tetraazatricyclo [8. The structure of Etizolam is closely related to benzodiazepines like Valium and Xanax aka alprazolam, only the phenyl ring of the molecule is replaced with a thiophene ring.
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You will find the same products and many more! We have designed a newer, more neutral branding in lieu of coming regulatory changes. What Is Etizolam? Etizolam is NOT a benzodiazepine compound nor is it a derivative of benzodiazepines. It is a thieontriazolodiazepine. All of the research products sold on our site are strictly NOT for in vivo research involving humans or animals, nor is it approved or sold for human or animal consumption.
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Applicants are processed quickly so you can spend more time on your Research. Register Your Account. Latest New from our Blog.Etizolam, also known as Etilaam or Etizest, is a synthetic designer analog of Thienodiazepine and is a depressant substance which causes anti-anxiety, anti-stress and muscle relaxing effects similar to those of benzodiazepine. It is a popular a research chemical available as pills, powder or solution.
The molecular weight of this drug has been calculated to be The recommended storage temperature for the drugs is either room temperature or between 20 o C to 25 o C while the stability of the molecule of this drug is known to be equal to or greater than two to three years. The Etizolam although is listed as a research chemical but it has also been actively prescribed for use in medical treatment for anxiety.
Etizolam was first introduced in as a gray research chemical. It has since become extremely popular due to its low cost, high levels of products and a wide range of applications. The origins of the formula are unclear though and have been linked to research dating as back as the s.
Etizolam is known to cause anti-depressant, anti-anxiety, and muscle relaxation effects on administration and has been prescribed for medical use in such cases as well. This drug is also known to be used for stress reduction and memory relocation. The drug is also known to be used by people for recreational purposes as it can produce effects such as ego inflation, emotional suppression, and sense of sobriety.
It has also been used by people for recreational purposes. The drug has wide-ranging application and has been used by both researchers and common people. The drug causes effects of physical, psychological and subjective effects when administered.
The drug causes a feeling of weakness and motor loss control. The drug also causes feelings of sleepiness and sleep depravity. It can also cause short-term memory loss by impacting the hippocampus region in the brain. Motivational and energy level suppression is also caused by the drug while it also affects the thought processing ability of human brain as well.
The dosage of the drug ranges from 0. Light doses of the drug range from 0.